Graceful Aging
Aging is an inevitable process. It refers to the decline in function due to accumulated cellular damage that can progressively worsen health over time. No food, supplement, pill, or powder can currently prevent aging altogether.
And while you can’t stop aging, you can take steps to delay the aging process and improve some biomarkers related to aging (like cholesterol, glucose, and inflammation). Eating a healthy diet, sleeping well, reducing stress, and participating in both strength and cardiovascular exercise can all promote healthy aging and increase longevity.
But if you’ve already built a solid foundation in those areas of life, you may still wonder if there’s more you can do to ensure your healthy longevity – perhaps you’ve wondered if any supplements that may slow down the aging process…
Being a focus of research for decades, scientists have identified a large number of substances with anti-aging properties, many of which can be taken as supplements by those looking for natural ways to slow down aging process and prevent age-related diseases.
Longevity Essential - Age Support Supplement
As we enter middle age, there is a gradual decline in our body’s intracellular energy production, leading to various skin changes such as wrinkles, sagging, pigmentation, dry skin and overall signs of ageing. These clinical signs mirror what is happening internally, as our cells reduce their efficiency to make energy (NAD+), causing increased insulin resistance, elevated blood sugar, weight gain and increased cardiovascular disease and cancer risk. It also makes us feel tired, and less vital.
Achieve Beautiful Skin & Long-term Health by Optimising Your Metabolism. Don’t settle for a single ingredient to support healthy aging. AEON™ is the only product to offer an 11-compound longevity complex that addresses everything from oxidative stress, glycation, telomere shortening, to side reactions, and mutations*.
New studies show each of these compounds when taken daily extend life in mice & primates up to 30% *. Promising studies in humans are currently underway.
Furthermore, a synergistic effect happens when they’re compounded that has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death *.
Below we’ll break down the origin, and effects of each ingredient in AEON™ with links to independent, peer-reviewed studies.
Compounds In AEON™
A U.S.-based bio-tech company that focuses on Research & Development in the field of gerontology, and longevity medicine. It comprises a small group of microbiologists, doctors, and biotech entrepreneurs dedicated to funding longevity research across the World in an effort to develop supplements, and pharmaceuticals that may slow or one day stop human aging.
In 2021 the company finally released their first product AEON: “It was very important to us that our first product be formulated with the most researched, and cutting edge ingredients available on the market. AEON was created to be an all-in-one longevity focused supplement. Each compound carefully chosen for its stand-alone benefits as well as its synergistic ones paired with the other 10.” – Prof. Michael Morgan
We don’t waste money on flashy marketing campaigns, or commercials, because we’re not here to persuade you to buy our products. Our goal is to offer already informed consumers a more affordable, unrivaled all-in-one NAD+ supplement.
Ingredients
AEON™ is the World’s best anti-aging supplement and the only one that contains a full spectrum 11-compound complex. Each dose consists of two easy to swallow capsules that contain:
- Nicotinamide DUO™ (as 400mg Mono + 100mg Riboside*)
- Quercetin (from Sophora japonica) – 250mg
- Trans-Resveratrol (from Polygonum cuspidatum) – 150mg
- L-Theanine – 100mg
- Fisetin (from Rhus succedanea stem) – 100mg
- Astragalus (from Astragalus membranaceus) – 100mg
- TMG (as Betaine Anhyrous) – 85mg
- Spermidine (as Spermidine Trihydrochloide) – 10mg
- Piperine (from Piper Nigrum) – 10mg
- Epigallocatechin gallate (from Camellia sinesis) – 100mg
Testing for heavy metals, contaminants, and potency is conducted on all raw materials, and randomly on finished product by in-house, and 3rd party laboratories yearly. Please email us to view the most recent report.
Nicotinamide DUO™ is a proprietary NAD+ precursor developed by Perpetua.Life® Biotech based on a an 80/20 blend of Mono/Riboside (LNR) which has been found to boost NAD+ level even higher than Riboside alone.
NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair and gene expression. [22, 23]
NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s. [23]
Studies have shown that supplementing with NAD+ precursors like NR restores NAD+ levels and prevents age-related physical decline. [24]
For example, a study in aging subjects demonstrated that supplementing orally with Nicotinamide Mono prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity. [24B]
A 2019 study in 12 men with an average age of 75 showed that supplementing with up to 1 gram of Nicotinamide daily for 21 days increased NAD+ levels in skeletal muscle and reduced levels of inflammatory proteins in the body. [25]
Fisetin is a plant pigment (flavonoid) compound that’s considered a senotherapeutic, meaning it can kill senescent cells.
Fisetin as an anti-cancer agent targeting the growth signaling pathways. [F01]
Rodent studies suggest that it may reduce the number of senescent cells in tissues and extend lifespan. [41]
Fisetin & its role in chronic diseases. [F02]
Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy. [F03]
Fisetin & Quercetin: Promising flavonoids with chemo-preventive potential. [F03]
Fisetin: A dietary antioxidant for health promotion. [F04]
Exploring the molecular targets of dietary flavonoid Fisetin in cancer. [F05]
Astragalus membranaceus is a stress-reducing herb used in traditional Chinese medicine. It may help combat aging by reducing oxidative stress, promoting immune function and preventing cellular damage. [40]
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro. [A2]
Astragalus membranaceus: A review of its protection against inflammation and gastrointestinal cancers. [A1]
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives with astragalus. [A3]
Experimental and clinical studies of mechanisms of the anti-aging effects of chemical compounds in Astragalus membranaceus. [A4]
Astragalus (a traditional Chinese medicine) for treating chronic kidney disease. [A5]
Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of fruit flies, yeasts, and nematodes. [42]
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a periodontitis model. [R5]
Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. [Q4]
Effects of Resveratrol and other polyphenols on Sirt1: Relevance to brain function during aging. [R4]
Resveratrol, an Nrf2 activator, alleviates aging-related progressive renal injury. [R3]
Role of Resveratrol in regulation of cellular defense systems against oxidative stress. [R2]
Effect of Resveratrol and pterostilbene on aging and longevity. [R1]
Quercetin is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine.
Quercetin has antioxidant and anti-inflammatory effects which might help reduce inflammation, kill cancer cells, control blood sugar and help prevent heart disease. [Q1]
Quercetin in cancer prevention and therapy. [Q2]
Fisetin & Quercetin: Promising flavonoids with chemo preventive potential. [F03]
Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer. [Q3]
A preliminary investigation demonstrating the effect of Quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. [Q4]
Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. [Q4B]
Epigallocatechin Gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers, as well as other health conditions like heart disease and may prevent or slow fibroid growth. [9, 10, 11, 12]
Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development.
EGCG may slow aging by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signalling pathway (AMPK).
It also induces autophagy, the process by which your body removes damaged cellular material. [12]
EGCG intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light. [13, 14, 15]
Spermidine has anti-inflammatory & anti-antioxidant properties and can also enhance respiration and metabolic function. Increased dietary spermidine intake is thought to reduce the risk of diseases like cancer, metabolic disease, heart disease and neurodegeneration. [1]
It can also improve memory and slow cognitive decline, as autophagy clears Alzheimer’s-causing amyloid-beta plaques in the brain and can thereby be used to prevent memory loss in older people suffering from mild dementia. [2]
TMG (Trimethylglycine) is produced by our body and is found naturally in beetroot and other foods. It’s also available as a supplement, sometimes used to enhance athletic performance and improve heart & liver health.
TMG is involved in a chemical process called methylation, which is essential for DNA production. [NIH Source]
TMG has outstanding effects on controlling homocysteine levels in the blood. Homocysteine significantly increases around the middle stage of life, and it’s linked to the development of heart disease and stroke.
In a breast cancer study, having more TMG in patients’ diets was linked to fewer deaths from cancer. [NIH Source]
In another study of more than 2800 lung cancer patients, high betaine intake was found to be protective against lung cancer. [NIH Source]
A study including 193 senior citizens showed that an increase in TMG was linked to improvements in response time, memory, and brain function. People whose TMG levels went up the most also saw the most improvement in their memories. [NIH Source]
Additionally, TMG is also being explored as treatment for other neurological disorders such as Alzheimer’s disease. [NIH Source]
L-Theanine is an amino acid concentrated in certain teas, including green tea. It may help protect against mental decline and has been shown to extend the lifespan of roundworms by around 5%. [35, 36]
l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. [T1]
Protective effect and mechanism of Theanine on Lipopolysaccharide-induced inflammation and acute liver injury. [T2]
L-Theanine extends lifespan of adult Caenorhabditis elegans. [T3]
The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. [T4]
l-Theanine prevents long-term affective and cognitive side effects of adolescent Δ-9-Tetrahydrocannabinol exposure and blocks associated molecular and neuronal abnormalities in the Mesocorticolimbic Circuitry. [T5]
Frequently Asked Questions
How to take AEON™?
For best absorption, It's advised AEON™ be taken with a full meal. Recent research has shown great promise with ED administration around noon. A full dose is considered 2 capsules, that can be taken together or split AM / PM.
How to choose the dosage?
The exact dosage of each compound in our formula is determined by our laboratory team, and based on the latest clinical research. They look at both the effective therapeutic dose, as well as what your body is actually able to effectively absorb.
Inclusion of some compounds is also weighted against possible side effects or negative interaction with other drugs. We aim to create the safest formula, that can also be safely taken by the largest amount of people.
Can I take AEON™ indefinitely?
Yes, our capsules are intended to be taken indefinitely as a dietary supplement. AEON™ is most effective when used daily over an extended period of time.
Is AEON™ designed to be consumed by women and men?
AEON™ is for anyone looking to support their cellular health, and combat the symptoms of aging.
Is 500mg too low/high a serving for Nicotinamide DUO™ ?
500mg is a sufficient daily serving. The serving size of 500mg DUO™ per day is supported by multiple published human clinical studies. This serving size is clinically shown to increase Nicotinamide Adenine Dinucleotide (NAD+) levels in people and maintain those elevated NAD+ levels with continued daily use.
However, you can safely double your dose to 1,000mg of Nicotinamide DUO™ (4 capsules per day) if you so choose.
What makes AEON™ worth the cost?
Every ingredient in AEON™ has been carefully selected to maximize its effectiveness. If you purchased each of AEON™ compounds separately the cost would be north of $480 per month.
Is AEON™ third party tested?
AEON™ is manufactured in the United States, from the highest quality ingredients in partnership with a GMP/NSF certified, FDA registered facility in New York.
Potency, and Heavy Metal testing is conducted on finished product by Twin Arbor Labs in Paso Robles, California; an independent GLP compliant laboratory, accredited to ISO/IEC 17025:2017.
Here at Perpetua.Life we pride ourselves on unrivaled quality standards, and transparency. All of our products are formulated, manufactured, and distributed to the same standards of the pharmaceutical industry.
For the latest lab test results refer to the "Testing" tab in the product description.
Where is AEON™ manufactured?
AEON™ is manufactured in the United States, from the highest quality ingredients in partnership with a GMP/NSF certified, FDA registered facility in New York.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
** Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.
** Individual tolerance and responses dietary supplements may vary. We do not guarantee individual results and do not take responsibility for any unexpected side effects.